Context Recent reports highlight gaps between guidelines-based treatment recommendations and evidence from clinical trials that supports those recommendations. Strengthened reporting requirements for studies registered with ClinicalTrials.gov enable …
Altruism and trust lie at the heart of research on human subjects. Altruistic individuals volunteer for research because they trust that their participation will contribute to improved health for others and that researchers will minimise risks to …
In 2005, the International Committee of Medical Journal Editors (ICMJE) initiated a policy requiring investigators to deposit information about trial design into an accepted clinical trials registry before the onset of patient enrolment. 1 This …
All parties associated in clinical trials—patients, doctors, scientists, industry—share a common desire for a vigorous clinical research enterprise that brings innovations to patients as quickly as possible. However, recent scandals in the UK and …
Discrepancies between pre-specified and reported outcomes are an important source of bias in trials. Despite legislation, guidelines and public commitments on correct reporting from journals, outcome misreporting continues to be prevalent. We aimed …
In psychology, preregistration is the most widely used method to ensure the confirmatory status of analyses. However, the method has disadvantages: Not only is it perceived as effortful and time-consuming, but reasonable deviations from the analysis …
Preregistration forces researchers to front-load a lot of decision-making to an early stage of a project. Choosing which preregistration platform to use is one of those early decisions, and because a preregistration cannot be moved, that choice is …
Registered Reports: Peer review before results are known to align scientific values and practices.
Registered Reports is a publishing format used by over 250 journals that emphasizes the importance of the research question and the quality of …
Improving the usability of psychological research has been encouraged through practices such as prospectively registering research plans. Registering research aligns with the open-science movement, as the registration of research protocols in …
Preregistration of studies is a recognized tool in clinical research to improve the quality and reporting of all gained results. In preclinical research, preregistration could boost the translation of published results into clinical breakthroughs. …