Finance

An open source pharma roadmap

In an Essay, Matthew Todd and colleagues discuss an open source approach to drug development. This Essay outlines how open source methods of working could be applied to the discovery and development of new medicines. There are many potential …

ARRIVE has not ARRIVEd: Support for the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines does not improve the reporting quality of papers in animal welfare, analgesia or anesthesia

Poor research reporting is a major contributing factor to low study reproducibility, financial and animal waste. The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines were developed to improve reporting quality and many journals …

PBFJ Editorial … Engaging with responsible science. “OPEN FOR BUSINESS” – Launching the PBFJ pre-registration publication initiative

This editorial note is an “action-based” follow-up to the previous PBFJ Editorial published in September 2021 … “A Declaration about Responsible Science” (Faff, 2021a). In that prior editorial, I made a very clear statement that “PBFJ is moving on a …

The Economics of Reproducibility in Preclinical Research

Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of …