Clinical Research

Publication bias in clinical research

In a retrospective survey, 487 research projects approved by the Central Oxford Research Ethics Committee between 1984 and 1987, were studied for evidence of publication bias. As of May, 1990, 285 of the studies had been analysed by the …

Publication of NIH funded trials registered in ClinicalTrials.gov: Cross sectional analysis

Objective To review patterns of publication of clinical trials funded by US National Institutes of Health (NIH) in peer reviewed biomedical journals indexed by Medline. Design Cross sectional analysis. Setting Clinical trials funded by NIH and …

The ClinicalTrials.gov Results Database — Update and Key Issues

BACKGROUND The ClinicalTrials.gov trial registry was expanded in 2008 to include a database for reporting summary results. We summarize the structure and contents of the results database, provide an update of relevant policies, and show how the data …

Trial registration 10 years on

This month marks the tenth anniversary of the landmark decision by the International Committee of Medical Journal Editors to make journals require “registration of any clinical trials in a public trials registry at or before the time of first patient …